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Mass Spectrometric ITEM-FOUR Analysis Reveals Coding Single Nucleotide Polymorphisms in Human Cardiac Troponin T That Evade Detection by Sandwich ELISAs Which Use Monoclonal Antibodies M7 and M11.7 from the Elecsys Troponin T® Assay

2025-04-15

Abstract excerpt

Immunoassays for cardiac troponin, such as the Elecsys® hs-TnT, have become the gold standard for myocardial infarction diagnostics. While various protein/chemical factors affecting the troponin complex and, thus, its diagnostic accuracy have been investigated, the role of coding single nucleotide polymorphisms remains underexplored. To evaluate potential cSNP-induced interference with antibody binding in the...

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Literature Corpus work
2bfcfb9b-ba17-5e73-a92b-23489e3e4653
DOI
10.20944/preprints202504.1025.v1
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Mass Spectrometric ITEM-FOUR Analysis Reveals Coding Single Nucleotide Polymorphisms in Human Cardiac Troponin T That Evade Detection by Sandwich ELISAs Which Use Monoclonal Antibodies M7 and M11.7 from the Elecsys Troponin T® AssayDOI 10.20944/preprints202504.1025.v1
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