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Article

Modeling Hypertrophic Cardiomyopathy-Related MYH7 Variants: Insights into Structural Changes and Cardiovascular Drug-Binding Affinities.

Biological & pharmaceutical bulletin - 1 Jan 2026

Widjaja Nadia, Dermawan Doni, Tan Santi, Simatupang Stefeny T, Yulandi Adi, Tjandrawinata Raymond R

Abstract excerpt

Mutations in the MYH7 gene, which encodes β-myosin heavy chain (β-MHC), are a significant cause of hypertrophic cardiomyopathy (HCM). These variants may lead to variable clinical outcomes, thereby influencing responsiveness to targeted therapies such as mavacamten, a cardiac myosin inhibitor. In this study, we employed AlphaFold modeling to construct structural models of both wild-type (WT) and mutant β-MHC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42203436
DOI: 10.1248/bpb.b26-00025

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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