Article

Engraftment of allotransplantated tumour cells in adult <i>rag2</i> mutant <i>Xenopus tropicalis</i>

2021-11-15

Abstract excerpt

Modelling human genetic diseases and cancer in lab animals has been greatly aided by the emergence of genetic engineering tools such as TALENs and CRISPR/Cas9. We have previously demonstrated the ease with which genetically engineered Xenopus models (GEXM) can be generated. This included the induction of autochthonous tumour formation by injection of early embryos with Cas9 recombinant protein loaded with sgRNAs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b8cef9b-77a0-5dd9-afc1-2cf3317ef290
DOI: 10.1101/2021.11.15.468684

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Engraftment of allotransplantated tumour cells in adult <i>rag2</i> mutant <i>Xenopus tropicalis</i>DOI 10.1101/2021.11.15.468684Read

Cancer Models in Xenopus tropicalis by CRISPR/Cas9 Mediated Knockout of Tumor Suppressors.Semantic proximity Read

Xenopus tropicalis as a model organism for genetics and genomics: past, present, and future.Semantic proximity Read

Optimized cell transplantation using adult rag2 mutant zebrafish.Semantic proximity Read

Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.Semantic proximity Read

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalisSemantic proximity Read

Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus.Semantic proximity Read

Leapfrogging: primordial germ cell transplantation permits recovery of CRISPR/Cas9-induced mutations in essential genes.Semantic proximity Read

Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.Semantic proximity Read

Engineered T cells directed at tumors with defined allelic loss.Semantic proximity Read

NINJA: an inducible genetic model for creating neoantigens <i>in vivo</i>Semantic proximity Read

Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cellsSemantic proximity Read

Genetic analysis of Xenopus tropicalis.Semantic proximity Read