Article

Therapeutic approach with commercial supplements for pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels.

2022-06-02

Abstract excerpt

<title>Abstract</title> <p>In this manuscript, we examined the therapeutic effectiveness of pantothenate, panthetine, antioxidants (vitamin E and omega 3) and mitochondrial function boosting supplements (L-carnitine and thiamine) in mutant PANK2 cells with residual expression levels. <h4>Results:</h4> Commercial supplements, pantothenate, pantethine, vitamin E, omega 3, carnitine and thiamine were able to elimina...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b793257-9d82-506d-8fdf-8cf188e123a3
DOI: 10.21203/rs.3.rs-1629815/v4

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic approach with commercial supplements for pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels.DOI 10.21203/rs.3.rs-1629815/v4Read

Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated NeurodegenerationSemantic proximity Read

Redesigning therapies for pantothenate kinase-associated neurodegeneration.Semantic proximity Read

Alpha-Lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levelsSemantic proximity Read

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation.Semantic proximity Read

Atypical Pantothenate Kinase-Associated Neurodegeneration with Variable Phenotypes in an Egyptian FamilySemantic proximity Read

Down Regulation Of The Expression Of Mitochondrial Phosphopantetheinyl-Proteins In Pantothenate Kinase-Associated Neurodegeneration: Pathophysiological Consequences and Therapeutic PerspectivesSemantic proximity Read

Rational Design of Novel Therapies for Pantothenate Kinase-Associated Neurodegeneration.Semantic proximity Read

Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.Semantic proximity Read

4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.Semantic proximity Read

Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name.Semantic proximity Read

Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.Semantic proximity Read

Pantothenate-kinase associated neurodegeneration (PKAN) "eye of the tiger" sign.Semantic proximity Read