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Article

Redesigning therapies for pantothenate kinase-associated neurodegeneration.

The Journal of biological chemistry - 1 Mar 2022

Munshi Muhammad I, Yao Sarah J, Ben Mamoun Choukri

Abstract excerpt

Pantothenate kinase-associated neurodegeneration (PKAN) is an incurable rare genetic disorder of children and young adults caused by mutations in the PANK2 gene, which encodes an enzyme critical for the biosynthesis of coenzyme A. Although PKAN affects only a small number of patients, it shares several hallmarks of more common neurodegenerative diseases of older adults such as Alzheimer's disease and Parkinson's...

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Identifiers

PMID: 35041826
DOI: 10.1016/j.jbc.2022.101577
PMCID: PMC8861153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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