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Article

Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population.

JAMA cardiology - 1 Nov 2024

Aung Nay, Nicholls Hannah L, Chahal C Anwar A, Khanji Mohammed Y, Rauseo Elisa, Chadalavada Sucharitha, Petersen Steffen E, Munroe Patricia B, Elliott Perry M, Lopes Luis R

Abstract excerpt

Importance: The population prevalence of cardiac transthyretin amyloidosis (ATTR) caused by pathogenic variation in the TTR gene (vATTR) is unknown. Objective: To estimate the population prevalence of disease-causing TTR variants and evaluate associated phenotypes and outcomes. Design, Setting, and Participants: This population-based cohort study analyzed UK Biobank (UKB) participants with whole-exome sequencing,...

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Amyloid Neuropathies, Familial
Atrial Fibrillation
Biological Specimen Banks
Electrocardiography
Heart Failure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39196575
DOI: 10.1001/jamacardio.2024.2190
PMCID: PMC11359106

Genes

TTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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