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Article

Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy.

Skeletal muscle - 20 Jun 2025

Widrick Jeffrey J, Lambert Matthias R, de Souza Leite Felipe, Jung Youngsook Lucy, Park Junseok, Conner James R, Lee Eunjung Alice, Beggs Alan H, Kunkel Louis M

Abstract excerpt

BACKGROUND: Dystrophin-deficient zebrafish larvae are a small, genetically tractable vertebrate model of Duchenne muscular dystrophy that is well suited for early-stage therapeutic development. However, current approaches for evaluating their mobility, a physiologically relevant therapeutic outcome, yield data of low resolution and high variability that provides minimal insight into potential mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40542412
DOI: 10.1186/s13395-025-00382-6
PMCID: PMC12180146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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