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Article

Myotonia congenita-associated mutations in chloride channel-1 affect zebrafish body wave swimming kinematics.

PloS one - 1 Jan 2014

Cheng Wei, Tian Jing, Burgunder Jean-Marc, Hunziker Walter, Eng How-Lung

Abstract excerpt

Myotonia congenita is a human muscle disorder caused by mutations in CLCN1, which encodes human chloride channel 1 (CLCN1). Zebrafish is becoming an increasingly useful model for human diseases, including muscle disorders. In this study, we generated transgenic zebrafish expressing, under the control of a muscle specific promoter, human CLCN1 carrying mutations that have been identified in human patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25083883
DOI: 10.1371/journal.pone.0103445
PMCID: PMC4118878

Genes

CLCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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