Article

A pair of non-competing neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model

2021-04-16

Abstract excerpt

<h4>ABSTRACT</h4> TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly generate human monoclonal antibodies. After immunizing these mice against the spike protein of SARS-CoV-2, we identified 29 hybridoma antibodies that reacted with the SARS-CoV-2 spike protein. Nine antibodies neutralized SARS-CoV-2 infection at IC50 values in the subnanomolar range....

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Literature Corpus work: 2a65772c-df0b-5e03-92e8-93e654503f07
DOI: 10.1101/2021.04.16.440101

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