Back to search

Article

Alpha globin gene deletions in amelioration of clinical severity in beta haemoglobinopathy subjects with the β<sup>0</sup>/β<sup>+</sup> genotype

2020-05-30

Abstract excerpt

Thalassemia is the commonest inherited hemoglobinopathy worldwide. Variation of clinical symptoms entail differences in disease-onset and transfusion requirements. Our objective was to investigate the role of alpha gene deletions in modulating the clinical heterogeneity of thalassemia syndromes. A total of 214 individuals with diagnosed beta-thalassemia major/intermedia were included in the study. Beta globin muta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2a460b90-04c1-5534-9c01-6fcbf4a4d61e
DOI
10.1101/2020.05.29.20117135
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Alpha globin gene deletions in amelioration of clinical severity in beta haemoglobinopathy subjects with the β<sup>0</sup>/β<sup>+</sup> genotypeDOI 10.1101/2020.05.29.20117135
Effect of deletions in the α-globin gene on the phenotype severity of β-thalassemia.Semantic proximity
Alpha globin gene alterations modifying the phenotype of homozygous beta thalassaemiaSemantic proximity
Pathophysiology of beta thalassemia--a guide to molecular therapies.Semantic proximity
Phenotypic effect of α-globin gene numbers on Indian sickle β-thalassemia patients.Semantic proximity
[Beta thalassemia: molecular pathogenesis and clinical variability].Semantic proximity
Genetic determinants of phenotype in beta-thalassemia.Semantic proximity
Molecular Characterization of β-Thalassemia Intermedia in Southeast Iran.Semantic proximity
The search for genetic modifiers of disease severity in the β-hemoglobinopathies.Semantic proximity
α-Globin as a molecular target in the treatment of β-thalassemiaSemantic proximity
Beta-thalassaemia.Semantic proximity
Trans-acting genetic modifiers of clinical severity in heterozygous β-Thalassemia trait.Semantic proximity
Genetic factors affecting clinical severity in beta-thalassemia syndromes.Semantic proximity
Select a neighboring publication to make it the new centre.