Effect of deletions in the α-globin gene on the phenotype severity of β-thalassemia.

doi:10.1080/03630269.2022.2088381

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Article

Effect of deletions in the α-globin gene on the phenotype severity of β-thalassemia.

Hemoglobin - 1 Mar 2022

Saha Dipankar, Chowdhury Prosanto Kr, Panja Amrita, Pal Debashis, Nayek Kaustav, Chakraborty Gispati, Sharma Prashant, Das Reena, Basu Surupa, Chatterjee Raghunath, Basu Anupam

Abstract excerpt

Thalassemia is the most common inherited hemoglobinopathy worldwide. Variation of clinical symptoms in this hemoglobinopathy entails differences in disease-onset and transfusion requirements. The aim of this study was to investigate the role of α-globin gene deletions in modulating the clinical heterogeneity of β-thalassemia (β-thal) syndromes. A total number 270 β-thal subjects were enrolled. Hematological...

Topics

Genotype
Hemoglobinopathies
Humans
Mutation
Phenotype
alpha-Globins
alpha-Thalassemia
beta-Globins
beta-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 36000542
DOI: 10.1080/03630269.2022.2088381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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