Genetic determinants of phenotype in beta-thalassemia.

Abstract excerpt

Modifier genes are defined as inherited genetic variation that leads to a qualitative or quantitative difference in disease phenotype. This has made the prediction of the phenotype based upon the genotype more difficult. Beta-thalassemia phenotype is modified by co-existent other genetic alterations. Changes alpha/beta-globin ratio can either ameliorate the disease phenotype or increase the severity of the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to beta-Globins
• Share to beta-Thalassemia
• Share to Fetal Hemoglobin