Molecular Characterization of β-Thalassemia Intermedia in Southeast Iran.

Abstract excerpt

Inheritance of mild mutations within the β-globin gene and coinheritance of α-thalassemia (α-thal) are known as two important genetic modifiers in β-thalassemia (β-thal) intermedia (β-TI). We aimed to evaluate the spectrum of β- and α-thal mutations in β-TI patients in Southeast Iran. Common β- and α-globin gene mutations were detected by amplification refractory mutation system-polymerase chain reaction...

Topics

• DNA Mutational Analysis
• Female
• Gene Frequency
• Genotype
• Humans
• Iran
• Male
• Molecular Epidemiology
• Mutation
• Polymerase Chain Reaction
• alpha-Globins
• alpha-Thalassemia