Article

Neanderthal Introgressed COVID-19 Risk Locus 3p21.31 Under Positive Selection in East Asia via LZTFL1-Driven Ciliary Changes

2025-10-03

Abstract excerpt

The Neanderthal introgressed 3p21.31 locus has been repeatedly associated as a major host genetic determinant of severe COVID-19, particularly in European and South Asian populations. However, the evolutionary history and likely effector gene remain unclear. We investigated signatures of historical selection at this locus and the mechanism by which it might influence COVID-19 severity. Using 1000 Genomes Project d...

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Literature Corpus work: 2a3e3afd-e45f-5b9e-a424-301a6f365abc
DOI: 10.1101/2025.10.01.679818

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