The Neanderthal-Derived 3p21 Haplotype at LZTFL1 in Modern-Day Moroccans Is Associated With COVID-19 Severity and Further Suggests the Presence of Neanderthals in North Africa.

doi:10.1111/iji.70061

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The Neanderthal-Derived 3p21 Haplotype at LZTFL1 in Modern-Day Moroccans Is Associated With COVID-19 Severity and Further Suggests the Presence of Neanderthals in North Africa.

International journal of immunogenetics - 1 Oct 2026

Bouhouche Ahmed, Skhoun Hanaa, Baghdadi Jamila El, Yousfi Fatima-Zahra El

Abstract excerpt

There is considerable variability in the clinical presentation of COVID-19 among patients infected with SARS-CoV-2. Genome-wide association studies (GWASs) have identified the 12q24.13 and 3p21.31 regions, derived from Neanderthal DNA, as the human genetic loci most strongly associated with COVID-19 severity. We examined in this study the 3p locus in the Moroccan population by analysing allele and haplotype...

Read the complete abstract on PubMed

Topics

Adult
Female
Humans
Male
Middle Aged
Alleles
Chromosomes, Human, Pair 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

COVID-19

Gene Frequency

Genetic Predisposition to Disease

Genome-Wide Association Study

Haplotypes

Morocco

Neanderthals

North African People

Polymorphism, Single Nucleotide

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 42554622
DOI: 10.1111/iji.70061
PMCID: PMC13555320

Genes

LZTFL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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