Article
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.
Nature genetics - 1 Nov 2021
Downes Damien J, Cross Amy R, Hua Peng, Roberts Nigel, Schwessinger Ron, Cutler Antony J, Munis Altar M, Brown Jill, Mielczarek Olga, de Andrea Carlos E, Melero Ignacio, Gill Deborah R, Hyde Stephen C, Knight Julian C, Todd John A, Sansom Stephen N, Issa Fadi, Davies James O J, Hughes Jim R
Abstract excerpt
The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19) pandemic has caused millions of deaths worldwide. Genome-wide association studies identified the 3p21.31 region as conferring a twofold increased risk of respiratory failure. Here, using a combined multiomics and machine learning approach, we identify the gain-of-function risk A allele of an SNP, rs17713054G>A, as a probable...
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