Article

A Novel Viral Assembly Inhibitor Blocks SARS-CoV-2 Replication in Airway Epithelial Cells

2023-05-17

Abstract excerpt

<title>Abstract</title> <p>The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need for novel therapies with high genetic barriers to resistance. The small molecule PAV-104, identified through a cell-free protein synthesis and assembly screen, was recently shown to target host protein assembly machinery in a manner specific to viral assembly. Here, we investigated the capacity of...

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Literature Corpus work: 2a29a625-f3b5-5fbf-a4ca-4e0817f77a81
DOI: 10.21203/rs.3.rs-2887435/v1

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