Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

Abstract excerpt

Although plasma proteins may serve as important markers of disease risk in neurological conditions, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. In this study, we conducted genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations...

Topics

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• Gene Ontology
• Mendelian Randomization Analysis
• Molecular Sequence Annotation
• Parkinson Disease
• Proteome
• Scavenger Receptors, Class A
• Sialic Acid Binding Ig-like Lectin 3
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

2a11750c-09b7-5d6a-a7f7-a84b51898b2b

DOI

10.1101/558940