Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells in vitro

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and a catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the mono-, di-, and tri-methylation of histone H3 at Lys 27 (H3K27me3) to facilitate chromatin remodeling and gene silencing functions. The overexpression of EZH2 is associated with high levels of H3K27me3 in variou...

Topics

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• Acute Myeloid Leukemia Research
• Enhancer of Zeste Homolog 2 Protein
• Epigenesis, Genetic
• Epigenetics and DNA Methylation
• Histone Deacetylase Inhibitors Research
• Mutation
• Neuroblastoma Research and Treatments
• Polycomb Repressive Complex 2

Identifiers and source

Literature Corpus work

2968e104-0efe-5b2a-b968-729fbb717b75

DOI

10.21203/rs.3.rs-108186/v2