Article

Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

2020-10-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Dysregulation of epigenetics plays important roles in leukemogenesis and progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate acetylation and deacetylation of nuclear histone, aberrant activation of HDAC results in uncontrolled proliferation and differentiated blockage, HDAC inhibit...

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Literature Corpus work: 8c4e4c43-072c-577d-8c25-be0500de97be
DOI: 10.21203/rs.3.rs-89956/v1

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