Back to search

Article

A harmonized meta-knowledgebase of clinical interpretations of cancer genomic variants

2018-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Precision oncology relies on the accurate discovery and interpretation of genomic variants to enable individualized diagnosis, prognosis, and therapy selection. We found that knowledgebases containing clinical interpretations of somatic cancer variants are highly disparate in interpretation content, structure, and supporting primary literature, impeding consensus when evaluating variants and the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a3cd10e9-f6e6-5ffe-84b1-a624169afd00
DOI
10.1101/366856
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A harmonized meta-knowledgebase of clinical interpretations of cancer genomic variantsDOI 10.1101/366856
A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer.Semantic proximity
Evolution of the open-access CIViC knowledgebase is driven by the needs of the cancer variant interpretation communitySemantic proximity
The Precision Medicine Knowledge Base: an online application for collaborative editing, maintenance and sharing of structured clinical-grade cancer mutations interpretationsSemantic proximity
The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretationsSemantic proximity
CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase.Semantic proximity
A comprehensive personal omics clinical interpreter based on genomic and transcriptomic profilesSemantic proximity
From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.Semantic proximity
The CIViC knowledge model and standard operating procedures for curation and clinical interpretation of variants in cancerSemantic proximity
VarGuideAtlas: a repository of variant interpretation guidelines.Semantic proximity
CIViCpy: a Python software development and analysis toolkit for the CIViC knowledgebaseSemantic proximity
Resources for Interpreting Variants in Precision Genomic Oncology ApplicationsSemantic proximity
Utility of public knowledge bases for the interpretation of comprehensive tumor molecular profiling results.Semantic proximity
Select a neighboring publication to make it the new centre.