Article

Aldo-keto reductase 1C3, which contributes to skin barrier function, is downregulated by single nucleotide polymorphisms predominantly in females with early-onset psoriasis

2022-11-17

Abstract excerpt

The principal pathology of psoriasis is impaired skin barrier function, epidermal thickening, and granular layer loss. Exposure to extrinsic factors such as tobacco smoke and air pollutants is associated with the development of psoriasis. Aryl hydrocarbon receptors (AHRs) are activated by extrinsic factors associated with the development of psoriasis and act as transcriptional regulators. Expression of aldo-keto r...

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Identifiers and source

Literature Corpus work: 294881eb-7bab-51cb-bca6-bcaae8ec9925
DOI: 10.21203/rs.3.rs-2261002/v1

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