Article

Engineered superinfective Pf phage prevents dissemination of <i>Pseudomonas aeruginosa</i> in a mouse burn model

2022-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Pf is a filamentous bacteriophage integrated in the chromosome of most clinical isolates of Pseudomonas aeruginosa . Under stress conditions, mutations occurring in the Pf genome result in the emergence of super-infective variants of Pf (SI-Pf) that are capable of circumventing phage immunity; therefore SI-Pf can even infect Pf-lysogenized P. aeruginosa . Herein, we identified specific mutatio...

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Literature Corpus work: 293707fb-8a2e-5114-9bd6-607465f049a8
DOI: 10.1101/2022.12.05.519246

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