Article
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.
Breast cancer research and treatment - 1 Feb 2010
Sun Ramon C, Fadia Mitali, Dahlstrom Jane E, Parish Christopher R, Board Philip G, Blackburn Anneke C
Abstract excerpt
The glycolytic phenotype is a widespread phenomenon in solid cancer forms, including breast cancer. Dichloroacetate (DCA) has recently been proposed as a novel and relatively non-toxic anti-cancer agent that can reverse the glycolytic phenotype in cancer cells through the inhibition of pyruvate dehydrogenase kinase. We have examined the effect of DCA against breast cancer cells, including in a highly metastatic...
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