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Article

An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.

Journal of cell science - 1 May 2021

Barnea-Zohar Maayan, Winograd-Katz Sabina E, Shalev Moran, Arman Esther, Reuven Nina, Roth Lee, Golani Ofra, Stein Merle, Thalji Fadi, Kanaan Moien, Tuckermann Jan, Geiger Benjamin, Elson Ari

Abstract excerpt

Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs) and induces autosomal recessive osteopetrosis in humans and in mice. We show here that the fusion of wild-type murine monocytes to form OCLs is highly regulated, and that its extent is limited by blocking fusion between mature OCLs. In contrast, monocytes from homozygous R51Q SNX10 mice fuse uncontrollably, forming giant...

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Identifiers

PMID: 33975343
DOI: 10.1242/jcs.254979
PMCID: PMC8182410

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