Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Jul 2022

Perkins Brandy, Showel Margaret, Schoch Laura, Imus Philip H, Karantanos Theodoros, Yonescu Raluca, Morsberger Laura, Ghiaur Gabriel, Gladstone Douglas E, Jones Richard J

Abstract excerpt

The clinical course of chronic lymphocytic leukemia (CLL) is highly variable. Immunoglobulin heavy chain variable region (IgHV) mutation status is among the most important prognostic factors, with unmutated IgHV associated with inferior outcomes. CLL presumably arises from mature B cells. However, we hypothesized that IgHV unmutated CLL could arise early in B cell differentiation. We prospectively studied 29...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD19
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Flow Cytometry

Share to Heterografts

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Precursor Cells, B-Lymphoid

Source

Open in PubMed Open full text

Identifiers

PMID: 35343368
DOI: 10.1080/10428194.2022.2038375
PMCID: PMC9276631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia.PMID 35343368Read ↗

Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones.Semantic proximity Read ↗

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features.Semantic proximity Read ↗

Determining mutational status of immunoglobulin v genes in chronic lymphocytic leukemia: a useful prognostic indicator.Semantic proximity Read ↗

Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia.Semantic proximity Read ↗

Why Is the Immunoglobulin Heavy Chain Gene Mutation Status a Prognostic Indicator in Chronic Lymphocytic Leukemia?Semantic proximity Read ↗

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.Semantic proximity Read ↗

CD19 negative and dim precursor B-lineage acute lymphoblastic leukemias: real-world challenges in a targeted-immunotherapy eraSemantic proximity Read ↗

Prognostic value of immunoglobulin variable heavy chain gene mutation status: long term follow-up in a series of chronic lymphocytic leukemia patients.Semantic proximity Read ↗

New insights into the phenotype and cell derivation of B cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Inherited CD19 deficiency impairs signaling in plasma cellsSemantic proximity Read ↗

High CXCR3 on Leukemic Cells Distinguishes IgHV mut from IgHV unmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.