Article

Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction

2026-06-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : An anaerobe-dominant, <italic>Lactobacillus</italic> -deplete cervicovaginal microbiome is associated with adverse reproductive outcomes. <italic>Gardnerella vaginalis</italic> , a cervicovaginal anaerobe, alters cervicovaginal epithelial cell function, resulting in immune activation and barrier breakdown. Host-microbial mechanisms inducing this epitheli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8e7b380-3b6c-5461-8d3f-91d56949b70f
DOI: 10.21203/rs.3.rs-8552817/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunctionDOI 10.21203/rs.3.rs-8552817/v1Read

Multiomic analysis reveals that polyamines alter <i>G. vaginalis</i> -induced cervicovaginal epithelial cell dysfunctionSemantic proximity Read

Colonic spermidine promotes proliferation and migration of intestinal epithelial cellsSemantic proximity Read

Investigating Urine Microbiota and Metabolites in Female Patients with Cystitis Glandularis: A Comprehensive Analysis Using High-Throughput 16S rRNA Sequencing and MetabolomicsSemantic proximity Read

Differential Host Gene Expression Associated with Non-Lactobacillus-dominant Vaginal Microbiomes During PregnancySemantic proximity Read

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the DiseaseSemantic proximity Read

Mobiluncus mulieris Alters the Transcriptomic Profile of Cervicovaginal Epithelial Cells, Shedding Light on Molecular Drivers of Adverse Reproductive OutcomesSemantic proximity Read

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology AnalysisSemantic proximity Read

Cervicovaginal microbiome composition drives metabolic profiles in healthy pregnancySemantic proximity Read

Characteristics of the vaginal microbiota and vaginal metabolites in women with cervical dysplasiaSemantic proximity Read

Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategiesSemantic proximity Read

Characterisation of the Vaginal Microbiota Using Culturomics and Metagenomics Suggests Transplantation of Gut Microbiota Into the Vagina During Bacterial VaginosisSemantic proximity Read

Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategiesSemantic proximity Read