Article

Multiomic analysis reveals that polyamines alter <i>G. vaginalis</i> -induced cervicovaginal epithelial cell dysfunction

2025-11-20

Abstract excerpt

An anaerobe-dominant, Lactobacillus -deplete cervicovaginal microbiome is associated with adverse reproductive outcomes. Gardnerella vaginalis , a cervicovaginal anaerobe, alters cervicovaginal epithelial cell function, resulting in immune activation and barrier breakdown. Host-microbial mechanisms inducing this epithelial dysfunction remain unknown. We show microbe-specific alterations in cervicovaginal epithel...

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Literature Corpus work: 98764a7c-0894-51b0-81c6-0584da7f0c65
DOI: 10.1101/2025.11.20.689523

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