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Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

16 Mar 2020

Abstract excerpt

Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for...

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PMID: 32203155
DOI: 10.1038/s41380-020-0689-5

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