Article
Somatic mutations and ageing in silico.
Mechanisms of ageing and development - 1 Jan 2003
Kirkwood Thomas B L, Proctor Carole J
Abstract excerpt
Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with a dynamic profile that is consistent with them playing a causative role. We describe the...
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