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Article

Sensitivity to temozolomide in brain tumor initiating cells

13 Apr 2010

Abstract excerpt

Molecular alterations in glioblastoma have the potential to guide treatment. Here, we explore the relationship between temozolomide (TMZ) response and O(6)-methylguanine DNA methyltransferase (MGMT) status in brain tumor initiating cells (BTICs). Methylation, expression, and sensitivity were assessed in 20 lines; associations were evaluated by Fisher's exact test. Some BTICs were sensitive. Sensitivity to TMZ was...

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Share to Epigenetics and DNA Methylation
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PMID: 20388697
DOI: 10.1093/neuonc/noq032

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