Article

Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride

2020-07-15

Abstract excerpt

<title>Abstract</title> <p>Human steroid 5α-reductase 2 (SRD5α2) as a critical integral membrane enzyme in steroid metabolism catalyzes testosterone to dihydrotestosterone. Mutations on its gene have been linked to 5α-reductase deficiency and prostate cancer. Finasteride and dutasteride as SRD5α2 inhibitors are widely used anti-androgen drugs for benign prostate hyperplasia, which have recently been indicated in...

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Literature Corpus work: 7e59f9d8-0353-54ab-bc48-f3f1b3a809ff
DOI: 10.21203/rs.3.rs-40159/v1

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