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Article

5-Alpha reductase deficiency: a 40-year retrospective review.

Current opinion in endocrinology, diabetes, and obesity - 1 Dec 2014

Okeigwe Ijeoma, Kuohung Wendy

Abstract excerpt

PURPOSE OF REVIEW: 5-Alpha reductase is an enzyme responsible for the conversion of testosterone to dihydrotestosterone. This key enzyme is responsible for triggering masculinization of the male external genitalia. Discovery of 5-alpha reductase deficiency as a syndrome of disordered male sexual development led to our molecular understanding of the role that this key enzyme plays in male sexual differentiation....

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Identifiers

PMID: 25321150
DOI: 10.1097/MED.0000000000000116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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