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Article

EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development

27 Feb 2017

Abstract excerpt

BackgroundLarvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host.The molecular mechanisms controlling the behavior of germinative cells are largely unknown. Methodology/Principal findingsUsing in vitro...

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PMID: 28241017
DOI: 10.1371/journal.pntd.0005418

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