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Article

Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts

2016-03-01

Abstract excerpt

REDD1 is a transcriptional target gene of p53 and HIF-1, and an inhibitor of mTOR (mechanistic target of rapamycin) complex 1 (mTORC1)-signaling through PP2A-dependent interaction, making it an important convergence point of both tumor suppression and cell growth pathways. In accordance with this positioning, REDD1 levels are transcriptionally upregulated in response to a variety of cellular stress factors such as...

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Literature Corpus work
266658ab-f5ff-5b5e-b474-5ca0eecfe122
DOI
10.12688/f1000research.7691.1
Open publication

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Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblastsDOI 10.12688/f1000research.7691.1
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