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Article

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease

26 Aug 2022

Abstract excerpt

Microtubules (MTs) support a variety of neuronal functions, such as maintenance of cell structure, transport, and synaptic plasticity. Neuronal MTs are highly heterogeneous due to several tubulin isotypes and the presence of multiple post-translational modifications, such as detyrosination and acetylation. The tubulin tyrosination/detyrosination cycle is a key player in the maintenance of MT dynamics, as...

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PMID: 36092705
DOI: 10.3389/fcell.2022.926914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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