Article

Ancient retrotransposon-derived promoters for mammalian genomic imprinting

2025-07-18

Abstract excerpt

In mammalian genomic imprinting, RNA Pol II-driven transcription by upstream alternative promoters is responsible for establishing gametic DNA methylation on downstream Imprinting Control Regions (ICRs). According to surveys on germ cell transcripts, the alternative promoters for paternally expressed PEG3 , MEST and PLAGL1 are evolutionarily conserved and transcriptionally active mainly in the oocytes of the ma...

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Literature Corpus work: 260512db-4553-5e31-8937-b2db5b2d8e2d
DOI: 10.1101/2025.07.14.664778

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