Comparison of Bioinactive Growth Hormone Cases with Small for Gestational Age and Idiopathic Short Stature Cases

Abstract excerpt

<title>Abstract</title> <p>Background Short stature can result from various causes, including rare forms of growth hormone (GH) dysfunction like bioinactive GH, where GH is immunoreactive but biologically inactive due to GH1 gene mutations. Although GH levels are normal, affected children have low IGF-1 levels and show an increase in IGF-1 in response to rhGH therapy. This study compares the rhGH response in chil...

Topics

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• Growth Disorders
• Growth Hormone and Insulin-like Growth Factors
• Human Growth Hormone
• Infant, Newborn
• Infant, Small for Gestational Age
• Phenotype
• Pituitary Gland
• Transcription Factors

Identifiers and source

Literature Corpus work

25c17571-36f9-5e4f-812b-e414d7b93e23

DOI

10.21203/rs.3.rs-6530103/v1