Growth failure: ‘idiopathic’ only after a detailed diagnostic evaluation

doi:10.1530/ec-20-0585

Article

Growth failure: ‘idiopathic’ only after a detailed diagnostic evaluation

5 Feb 2021

Abstract excerpt

The terms 'idiopathic short stature' (ISS) and 'small for gestational age' (SGA) were first used in the 1970s and 1980s. ISS described non-syndromic short children with undefined aetiology who did not have growth hormone (GH) deficiency, chromosomal defects, chronic illness, dysmorphic features or low birth weight. Despite originating in the pre-molecular era, ISS is still used as a diagnostic label today. The...

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