Article
Clinical and molecular genetic analysis of children with severe short stature due to isolated growth hormone deficiency: insights from a South Indian cohort and predictors of growth response.
Pituitary - 22 Dec 2025
Dhivya Shanmugam, Sridhar Subbiah, Kathirvel M, Sreenivasan Palaniappan, Kuppusamy Nandini, Chellapillai Rahila, SenthilKumar Jayachandran
Abstract excerpt
PURPOSE: Isolated growth hormone deficiency (IGHD) is one of the treatable causes of short stature. We aimed to describe the clinical, biochemical, and molecular characteristics of IGHD and identify clinical predictors of mutation positivity and first-year height response to recombinant human growth hormone (rhGH). METHODS: Sixty-three children with IGHD who were on a minimum of one year of rhGH therapy were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.