Article

Revisiting Epithelial Carcinogenesis

2022-04-13

Abstract excerpt

The origin of cancer remains one of the most important enigmas in modern biology. This paper presents a hypothesis for the origin of carcinomas in which cellular aging and inflammation enable the recovery of cellular plasticity that may ultimately result in cancer. The process is described as the result of dedifferentiation undergone by epithelial cells in hyperplasia due to replicative senescence towards a mesenc...

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Literature Corpus work: 25a77eb4-ec53-552e-b2a9-21470f762942
DOI: 10.20944/preprints202204.0124.v1

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