Article

Germline Allelic Expression of Genes at 17q22 Locus Associates with Risk of Breast Cancer

2021-12-14

Abstract excerpt

<h4>A bstract </h4> Translation of GWAS findings into preventive approaches is challenged by identifying the causal risk variants and understanding their biological mechanisms. We present a novel approach using AE ratios to perform quantitative case-control analysis to identify risk associations, causal regulatory variants, and target genes. Using the breast cancer risk locus 17q22 to validate this approach, we fo...

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Literature Corpus work: 25982683-1bfc-52bb-ac45-283fef3977eb
DOI: 10.1101/2021.12.10.21267625

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