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Article

Germline allelic expression of genes at 17q22 locus associates with risk of breast cancer.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2022

Esteves Filipa, Xavier Joana M, Ford Anthony M, Rocha Cátia, Pharoah Paul D P, Caldas Carlos, Chin Suet-Feung, Maia Ana-Teresa

Abstract excerpt

INTRODUCTION: Translation of genome-wide association study (GWAS) ﬁndings into preventive approaches is challenged by the identification of the causal risk variants and the understanding of the biological mechanisms by which they act. We present using allelic expression (AE) ratios to perform quantitative case-control analysis as a novel approach to identify risk associations, causal regulatory variants, and...

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PMID: 35772352
DOI: 10.1016/j.ejca.2022.05.034

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