Article

P4-ATPase control over phosphoinositide membrane asymmetry and neomycin resistance

2025-03-03

Abstract excerpt

Neomycin, an aminoglycoside antibiotic, has robust antibacterial properties, yet its clinical utility is curtailed by its nephrotoxicity and ototoxicity. The mechanism by which the polycationic neomycin enters specific eukaryotic cell types remains poorly understood. In budding yeast, NEO1 is required for neomycin resistance and encodes a phospholipid flippase that establishes membrane asymmetry. Here, we show th...

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Literature Corpus work: 25481834-4fd1-5186-aaee-d5ae839ec8bb
DOI: 10.1101/2025.03.03.641220

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