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Article

A complex genetic interaction implicates that phospholipid asymmetry and phosphate homeostasis regulate Golgi functions.

PloS one - 1 Jan 2020

Miyasaka Mamoru, Mioka Tetsuo, Kishimoto Takuma, Itoh Eriko, Tanaka Kazuma

Abstract excerpt

In eukaryotic cells, phospholipid flippases translocate phospholipids from the exoplasmic to the cytoplasmic leaflet of the lipid bilayer. Budding yeast contains five flippases, of which Cdc50p-Drs2p and Neo1p are primarily involved in membrane trafficking in endosomes and Golgi membranes. The ANY1/CFS1 gene was identified as a suppressor of growth defects in the neo1Δ and cdc50Δ mutants. Cfs1p is a membrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32730286
DOI: 10.1371/journal.pone.0236520
PMCID: PMC7392219

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