Article

Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome

2020-08-17

Abstract excerpt

Congenital heart defects (CHDs) are the most common birth defect worldwide. The morbidity and mortality associated with these defects is compounded by increased frequency of fetal growth abnormalities. In the Ohia mouse model of hypoplastic left heart syndrome (HLHS), the double homozygous genotype is embryonically lethal at mid-pregnancy; a time in which optimal establishment of the placenta is crucial to fetal s...

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Literature Corpus work: 24f6a29c-75a2-5e61-873f-8d0e15ef1930
DOI: 10.1101/2020.08.17.252387

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