Article

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

2021-06-28

Abstract excerpt

High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action. Here we show that a compound termed lung cancer screen 3 (LCS3), previously selected for its ability to impair the growth of human lung adeno...

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Literature Corpus work: 24e2dc4f-d588-5dc9-a29a-f0c200e0c1b3
DOI: 10.1101/2021.06.28.450088

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