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Article

Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6.

PloS one - 1 Jan 2014

Jo Miran, Yun Hyung-Mun, Park Kyung-Ran, Park Mi Hee, Lee Dong Hun, Cho Seung Hee, Yoo Hwan-Soo, Lee Yong-Moon, Jeong Heon Sang, Kim Youngsoo, Jung Jae Kyung, Hwang Bang Yeon, Lee Mi Kyeong, Kim Nam Doo, Han Sang Bae, Hong Jin Tae

Abstract excerpt

Thiacremonone (2, 4-dihydroxy-2, 5-dimethyl-thiophene-3-one) is an antioxidant substance as a novel sulfur compound generated from High-Temperature-High-Pressure-treated garlic. Peroxiredoxin 6 (PRDX6) is a member of peroxidases, and has glutathione peroxidase and calcium-independent phospholipase A2 (iPLA2) activities. Several studies have demonstrated that PRDX6 stimulates lung cancer cell growth via an...

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Identifiers

PMID: 24618722
DOI: 10.1371/journal.pone.0091508
PMCID: PMC3950181

Genes

PRDX6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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