Article
Functional and transcriptomic analysis of the key unfolded protein response transcription factor HacA in Aspergillus oryzae.
Gene - 15 Nov 2016
Zhou Bin, Xie Jingyi, Liu Xiaokai, Wang Bin, Pan Li
Abstract excerpt
HacA is a conserved basic leucine zipper transcription factor that serves as the master transcriptional regulator in the unfolded protein response (UPR). To comprehensively evaluate the role of HacA in Aspergillus oryzae, a homokaryotic hacA disruption mutant (HacA-DE) and a strain that expressed a constitutively active form of HacA (HacA-CA) were successfully generated, and transcriptome analyses of these...
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