Back to search

Article

MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle

2020-12-24

Abstract excerpt

In type 2 diabetes (T2D), both muscle and liver are severely resistant to insulin action. Muscle insulin resistance accounts for more than 80% of the impairment in total body glucose disposal in T2D patients and is often characterized by an impaired insulin signaling. Mitsugumin 53 (MG53), a muscle-specific TRIM family protein initially identified as a key regulator of cell membrane repair machinery has been sugge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
240eec6b-1efd-52fa-bbd9-ad6c76930857
DOI
10.1101/2020.12.24.424288
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
MG53 is not a critical regulator of insulin signaling pathway in skeletal muscleDOI 10.1101/2020.12.24.424288
Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus.Semantic proximity
The human AMPKγ3 R225W mutation negatively impacts site-1 nucleotide binding and does not enhance basal AMPKγ3-associated activity nor glycogen production in human or mouse skeletal muscle.Semantic proximity
Cardiac effects and clinical applications of MG53Semantic proximity
Signaling and Gene Expression in Skeletal Muscles in Type 2 Diabetes: Current Results and OMICS PerspectivesSemantic proximity
The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytesSemantic proximity
An exercise-modifiable mitochondrial basis for skeletal muscle insulin resistance in humansSemantic proximity
The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin ResistanceSemantic proximity
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigeneticsSemantic proximity
Select a neighboring publication to make it the new centre.